Which camptothecin analogue is used to treat ovarian cancer?
Topotecan has been approved for ovarian cancer, cervical cancer and small cell lung cancer.
What drugs are camptothecin analogues?
Four CPT analogues have been approved and are used in cancer chemotherapy today, topotecan, irinotecan, belotecan, and trastuzumab deruxtecan. Camptothecin has also been found in other plants including Chonemorpha fragrans.
Which of the following camptothecin analogs is used to treat ovarian cancer?
Topotecan and irinotecan
Camptothecins produce their cytotoxic effects via inhibition of topoisomerase I, which causes single-strand breaks in DNA. Topotecan is indicated for the treatment of metastatic ovarian carcinoma, relapsed and refractory cervical cancer, and as second-line therapy for small cell lung cancer.
What is the brand name for camptothecin?
Camptosar is the trade name for irinotecan. Camptothecin-11 and CPT-11 are other names for irinotecan. In some cases, health care professionals may use the trade name camptosar or other names camptothecin-11 or CPT-11 when referring to the generic drug name irinotecan.
What cancer does camptothecin treat?
Camptothecin, an quinolone alkaloid, is used as a chemotherapeutic agent in the treatment of leukemia (Jones et al., 1997). Camptothecin complexes with type I DNA topoisomerase inhibiting both cleavage and religation reactions of DNA replication thus arresting growth of L.
Is irinotecan a camptothecin?
The hydrochloride salt of a semisynthetic derivative of camptothecin, a cytotoxic, quinoline-based alkaloid extracted from the Asian tree Camptotheca acuminata.
What class of drug is irinotecan?
Irinotecan is in a class of antineoplastic medications called topoisomerase I inhibitors. It works by stopping the growth of cancer cells.Apr 15, 2020
What is the mechanism of action of irinotecan?
Irinotecan interacts with cellular Topo I–DNA complexes and has S-phase-specific cytotoxicity [27]. Topoisomerases reduce DNA twisting and supercoiling that occur in selected regions of DNA as a result of essential cellular processes such as transcription, replication and repair recombination.
Is irinotecan a chemo drug?
Irinotecan is a type of chemotherapy. It is also known by its brand name Campto. It is a treatment for cancer that started in the bowel (bowel cancer).
What type of chemotherapy is irinotecan?
Irinotecan belongs to the group of medicines called antineoplastics (cancer medicines). It interferes with the growth of cancer cells, which are eventually destroyed.Nov 1, 2022