What type of alkaloid is camptothecin?
Camptothecin (CPT) is a monoterpene indole alkaloid originally isolated from the bark and stem of Camptotheca acuminata.
What is the classification of camptothecin?
Drug type: Irinotecan is an anti-cancer ("antineoplastic" or "cytotoxic") chemotherapy drug. This medication is classified as a "plant alkaloid" and "topoisomerase I inhibitor." (For more detail, see "How this drug works" section below).
What is the use of camptothecin drug?
Camptothecin, an quinolone alkaloid, is used as a chemotherapeutic agent in the treatment of leukemia (Jones et al., 1997). Camptothecin complexes with type I DNA topoisomerase inhibiting both cleavage and religation reactions of DNA replication thus arresting growth of L.
What is camptothecin an example of?
Camptothecin, an quinolone alkaloid, is used as a chemotherapeutic agent in the treatment of leukemia (Jones et al., 1997). Camptothecin complexes with type I DNA topoisomerase inhibiting both cleavage and religation reactions of DNA replication thus arresting growth of L.
What is the structure of camptothecin?
Camptothecin (CPT) is a monoterpene indole alkaloid originally isolated from the bark and stem of Camptotheca acuminata. It has a pentacyclic ring structure bearing a pyrrolo[3,4-β]-quinoline moiety.
What is the chemical structure of camptothecin?
Camptothecin is a pyranoindolizinoquinoline that is pyrano[3',4':6,7]indolizino[1,2-b]quinoline which is substituted by oxo groups at positions 3 and 14, and by an ethyl group and a hydroxy group at position 4 (the S enantiomer). It has a role as an EC 5.99.
What is the structure of Camptotheca?
CPT has a planar pentacyclic ring structure, that includes a pyrrolo[3,4-β]-quinoline moiety (rings A, B and C), conjugated pyridone moiety (ring D) and one chiral center at position 20 within the alpha-hydroxy lactone ring with (S) configuration (the E-ring).