What plant is camptothecin from?
Camptothecin (CPT) is an anticancer and antiviral alkaloid produced by the Chinese tree Camptotheca acuminata (Nyssaceae) and some other species belonging to the families Apocynaceae, Olacaceae, and Rubiaceae. Bark and seeds are currently used as sources for the drug.
What is camptothecin derived from?
Camptothecin is a naturally occurring alkaloid derived from the plant Camptotheca acuminata that was identified in an anticancer drug discovery screen in the 1960s.
What are the ingredients in camptothecin?
Although it is not fully resolved, it has been postulated that camptothecin is produced from strictosidine via strictosamide, 3 (S)-pumiloside and 3 (S)-deoxypumiloside.
What is the chemical composition of Camptotheca acuminata?
It is a pyranoindolizinoquinoline, a tertiary alcohol, a delta-lactone and a quinoline alkaloid. Camptothecin is an alkaloid isolated from the stem wood of the Chinese tree, Camptotheca acuminata.
What is the brand name for camptothecin?
Camptosar is the trade name for irinotecan. Camptothecin-11 and CPT-11 are other names for irinotecan. In some cases, health care professionals may use the trade name camptosar or other names camptothecin-11 or CPT-11 when referring to the generic drug name irinotecan.
What are other names for camptothecin?
Topoisomerase I Inhibitors (Camptothecins—Irinotecan, Topotecan) Camptothecin is a naturally occurring alkaloid derived from the plant Camptotheca acuminata that was identified in an anticancer drug discovery screen in the 1960s.
Is topotecan a camptothecin?
Warren Ross developed topotecan (NSC 609699),1 a semisynthetic, water-soluble analog of camptothecin.
What is the generic name for camptothecin?
Generic and brand names of antineoplastics CPTs include: Camptosar. Hycamtin. Irinotecan.
What are other names for irinotecan?
Irinotecan is a type of chemotherapy. It is also known by its brand name Campto. It is a treatment for cancer that started in the bowel (bowel cancer). This includes the colon and back passage (rectum).
What is the drug name for camptothecin?
Drug type: Irinotecan is an anti-cancer ("antineoplastic" or "cytotoxic") chemotherapy drug. This medication is classified as a "plant alkaloid" and "topoisomerase I inhibitor." (For more detail, see "How this drug works" section below).