What class of drug is camptothecins?
Drug type: Irinotecan is an anti-cancer ("antineoplastic" or "cytotoxic") chemotherapy drug. This medication is classified as a "plant alkaloid" and "topoisomerase I inhibitor." (For more detail, see "How this drug works" section below).
What drugs are camptothecin analogues?
Four CPT analogues have been approved and are used in cancer chemotherapy today, topotecan, irinotecan, belotecan, and trastuzumab deruxtecan. Camptothecin has also been found in other plants including Chonemorpha fragrans.
Which of the following camptothecin analogs is used to treat ovarian cancer?
Topotecan and irinotecan
Camptothecins produce their cytotoxic effects via inhibition of topoisomerase I, which causes single-strand breaks in DNA. Topotecan is indicated for the treatment of metastatic ovarian carcinoma, relapsed and refractory cervical cancer, and as second-line therapy for small cell lung cancer.
What type of alkaloid is camptothecin?
Camptothecin (CPT) is a monoterpene indole alkaloid originally isolated from the bark and stem of Camptotheca acuminata.
What is the classification of camptothecin?
Drug type: Irinotecan is an anti-cancer ("antineoplastic" or "cytotoxic") chemotherapy drug. This medication is classified as a "plant alkaloid" and "topoisomerase I inhibitor." (For more detail, see "How this drug works" section below).
What is the use of camptothecin drug?
Camptothecin, an quinolone alkaloid, is used as a chemotherapeutic agent in the treatment of leukemia (Jones et al., 1997). Camptothecin complexes with type I DNA topoisomerase inhibiting both cleavage and religation reactions of DNA replication thus arresting growth of L.
What is the structure of camptothecin?
Camptothecin (CPT) is a monoterpene indole alkaloid originally isolated from the bark and stem of Camptotheca acuminata. It has a pentacyclic ring structure bearing a pyrrolo[3,4-β]-quinoline moiety.
What is the chemical structure of camptothecin?
Camptothecin is a pyranoindolizinoquinoline that is pyrano[3',4':6,7]indolizino[1,2-b]quinoline which is substituted by oxo groups at positions 3 and 14, and by an ethyl group and a hydroxy group at position 4 (the S enantiomer). It has a role as an EC 5.99.
What is camptothecin an example of?
Camptothecin, an quinolone alkaloid, is used as a chemotherapeutic agent in the treatment of leukemia (Jones et al., 1997). Camptothecin complexes with type I DNA topoisomerase inhibiting both cleavage and religation reactions of DNA replication thus arresting growth of L.
What is the activity of camptothecin?
Camptothecin demonstrated strong anticancer activity in preliminary clinical trials but also low solubility and adverse drug reaction. Camptothecin is believed to be a potent topoisomerase inhibitor that interferes with the essential function of topoisomerase in DNA replication.Sep 11, 2007