What cancer does camptothecin treat?
Camptothecin, an quinolone alkaloid, is used as a chemotherapeutic agent in the treatment of leukemia (Jones et al., 1997). Camptothecin complexes with type I DNA topoisomerase inhibiting both cleavage and religation reactions of DNA replication thus arresting growth of L.
What is the target of camptothecin?
Camptothecins selectively target topoisomerase I (Top1) by trapping the catalytic intermediate of the Top1-DNA reaction, the cleavage complex. Hence, camptothecins represent a paradigm for targeting macromolecular interactions.
What is the function of camptothecin?
Camptothecin, an quinolone alkaloid, is used as a chemotherapeutic agent in the treatment of leukemia (Jones et al., 1997). Camptothecin complexes with type I DNA topoisomerase inhibiting both cleavage and religation reactions of DNA replication thus arresting growth of L.
What is the mechanism of camptothecins?
The primary mechanism of cell killing by CPT is S-phase-specific killing through potentially lethal collisions between advancing replication forks and topo-I cleavable complexes.
Which camptothecin analogue is used to treat ovarian cancer?
Topotecan has been approved for ovarian cancer, cervical cancer and small cell lung cancer.
What drugs are camptothecin analogues?
Four CPT analogues have been approved and are used in cancer chemotherapy today, topotecan, irinotecan, belotecan, and trastuzumab deruxtecan. Camptothecin has also been found in other plants including Chonemorpha fragrans.
What is the brand name for camptothecin?
Camptosar is the trade name for irinotecan. Camptothecin-11 and CPT-11 are other names for irinotecan. In some cases, health care professionals may use the trade name camptosar or other names camptothecin-11 or CPT-11 when referring to the generic drug name irinotecan.
Is irinotecan a camptothecin?
The hydrochloride salt of a semisynthetic derivative of camptothecin, a cytotoxic, quinoline-based alkaloid extracted from the Asian tree Camptotheca acuminata.
What is the mechanism of action of camptothecin in cancer?
The primary mechanism of cell killing by CPT is S-phase-specific killing through potentially lethal collisions between advancing replication forks and topo-I cleavable complexes.
Why is topotecan more useful than camptothecin?
In cell culture experiments, this agent was found to be twofold more cytotoxic than camptothecin, 25 times more lipophilic (thus more readily incorporated into liposomal bilayers), and more stable in human blood than any of the camptothecins in current clinical use.