What are the warnings for topotecan?
IMPORTANT WARNING:
Topotecan may cause a decrease in the number of blood cells made by your bone marrow. This increases the risk that you will develop a serious infection. You should not take topotecan if you already have a low number of blood cells.Oct 15, 2016
What is the main adverse effect of topotecan?
This medicine may cause a serious bowel problem called typhlitis (neutropenic enterocolitis), which could be life-threatening. Tell your doctor right away if you have a fever, abdominal or stomach pain, or a low count of white blood cells after receiving this medicine.Nov 1, 2022
What is the major adverse effect?
An undesired effect of a drug or other type of treatment, such as surgery. Adverse effects can range from mild to severe and can be life-threatening. Also called adverse event and adverse reaction.
What is the most common adverse effect of chemotherapy?
Tiredness. Tiredness (fatigue) is one of the most common side effects of chemotherapy. Many people having treatment feel tired a lot of the time or get tired very easily doing everyday tasks.
What are some common adverse effects associated with medications?
Common side effects include upset stomach, dry mouth, and drowsiness. A side effect is considered serious if the result is: death; life-threatening; hospitalization; disability or permanent damage; or exposure prior to conception or during pregnancy caused birth defect.Aug 8, 2022
How does topotecan cause cell death?
TPT induces topo I-dependent cleavable complex formation in tumor cells that are converted to both single- and double-strand breaks, leading to tumor cell death.Oct 24, 2017
How long can you take topotecan?
Topotecan is usually given every day for 3 to 5 days.Nov 1, 2022
Do you lose your hair with topotecan?
Some effects, like hair loss, may not be serious but may cause concern. Some unwanted effects may occur after treatment with topotecan has stopped. This medicine is available only with your doctor's prescription.Nov 1, 2022
Is topotecan successful?
The response rate observed with topotecan is between 6% and 11.8% in refractory patients and between 15% and 37% in sensitive patients. Median survival time is between 3.6 and 5.4 months in refractory patients and 5 and 8 months in sensitive patients.Dec 1, 2008
Is hair loss a side effect of topotecan?
Some effects, like hair loss, may not be serious but may cause concern. Some unwanted effects may occur after treatment with topotecan has stopped. This medicine is available only with your doctor's prescription.Nov 1, 2022