What are the side effects of topotecan chemotherapy?
Side Effects
- Black, tarry stools.
- blood in the urine or stools.
- body aches or pain.
- chest pain.
- congestion.
- difficult or labored breathing.
- dryness or soreness of the throat.
- hoarseness.
How long can you take topotecan?
Topotecan is usually given every day for 3 to 5 days.Nov 1, 2022
What does topotecan do in the body?
Topotecan is a type of chemotherapy drug called a topoisomerase 1 inhibitor. It works by blocking a chemical called topoisomerase 1. This chemical helps to separate and repair the DNA in cells when they divide. Cancer cells need to make and repair DNA in order to grow and multiply.
How successful is topotecan?
The response rate observed with topotecan is between 6% and 11.8% in refractory patients and between 15% and 37% in sensitive patients. Median survival time is between 3.6 and 5.4 months in refractory patients and 5 and 8 months in sensitive patients.Dec 1, 2008
What is the overall survival of topotecan?
Overall survival was significantly longer in the topotecan group (Fig 1; log-rank P = . 01). The median survival times were 13.9 weeks (95% CI, 11.1 to 18.6) in the BSC arm and 25.9 weeks (95% CI, 18.3 to 31.6) in the topotecan arm.Sep 21, 2016
What is the response rate of topotecan?
Topotecan is a topoisomerase I inhibitor widely available as an intravenous (IV) formulation for the treatment of patients with sensitive SCLC after failure of first-line therapy. Three phase II studies of single-agent IV topotecan have shown response rates of 14% to 38% among sensitive patients.Sep 21, 2016
Does topotecan cause hair loss?
v Hair loss is seen with topotecan, but some patients do experience less hair loss than others. The weekly regimens seem to be associated with less hair loss than the 5-day regimen. Regardless, hair growth should return upon completion of treatment.
What are the side effects of topotecan?
Side Effects
- Black, tarry stools.
- blood in the urine or stools.
- body aches or pain.
- chest pain.
- congestion.
- difficult or labored breathing.
- dryness or soreness of the throat.
- hoarseness.