Is topotecan successful?
Response rate was 24.3% in the topotecan arm and 18.3% in the CAV arm. Median survival was 25 weeks for topotecan and 24.7 weeks for CAV. The present study demonstrated that topotecan has significant advantages in controlling disease-related symptoms 8.
How long does it take for topotecan to work?
This 3-day or 5-day treatment is given again every 21 days until your body responds to the medicine. Each treatment usually takes at least 30 minutes. Topotecan often causes nausea and vomiting. It is very important that you continue to receive the medicine even if it makes you feel ill.Nov 1, 2022
How successful is topotecan?
The response rate observed with topotecan is between 6% and 11.8% in refractory patients and between 15% and 37% in sensitive patients. Median survival time is between 3.6 and 5.4 months in refractory patients and 5 and 8 months in sensitive patients.Dec 1, 2008
Do you lose your hair with topotecan?
Some effects, like hair loss, may not be serious but may cause concern. Some unwanted effects may occur after treatment with topotecan has stopped. This medicine is available only with your doctor's prescription.Nov 1, 2022
What cancer does topotecan treat?
Topotecan injection is used to treat patients with metastatic cancer (a cancer that has already spread) of the ovaries after other treatments have failed. This medicine is also used to treat a certain type of lung cancer called small cell lung cancer.Nov 1, 2022
What are the warnings for topotecan?
IMPORTANT WARNING:
Topotecan may cause a decrease in the number of blood cells made by your bone marrow. This increases the risk that you will develop a serious infection. You should not take topotecan if you already have a low number of blood cells.Oct 15, 2016
What is the main adverse effect of topotecan?
This medicine may cause a serious bowel problem called typhlitis (neutropenic enterocolitis), which could be life-threatening. Tell your doctor right away if you have a fever, abdominal or stomach pain, or a low count of white blood cells after receiving this medicine.Nov 1, 2022
Is hair loss a side effect of topotecan?
Some effects, like hair loss, may not be serious but may cause concern. Some unwanted effects may occur after treatment with topotecan has stopped. This medicine is available only with your doctor's prescription.Nov 1, 2022
What does topotecan do in the body?
Topotecan is a type of chemotherapy drug called a topoisomerase 1 inhibitor. It works by blocking a chemical called topoisomerase 1. This chemical helps to separate and repair the DNA in cells when they divide. Cancer cells need to make and repair DNA in order to grow and multiply.
What are the side effects of topotecan chemotherapy?
Side Effects
- Black, tarry stools.
- blood in the urine or stools.
- body aches or pain.
- chest pain.
- congestion.
- difficult or labored breathing.
- dryness or soreness of the throat.
- hoarseness.