Is camptothecin soluble in water?
Solubility: Soluble in DMSO (10mg/ml), methanol (40mg/ml), 0.1N sodium hydroxide (50mg/ml) or acetic acid; insoluble in water.
How do you dissolve camptothecin?
This product is soluble in DMSO (10 mg/ml). At higher concentrations, heating is required for the product to dissolve completely (approximately 10 minutes at 95 °C), but some precipitation occurs upon cooling to room temperature. It is also soluble in 1 N NaOH (50 mg/ml).
How do you dilute camptothecin?
Camptothecin is sparingly soluble in aqueous buffers. For maximum solubility in aqueous buffers, camptothecin should first be dissolved in DMSO and then diluted with the aqueous buffer of choice. Camptothecin has a solubility of approximately 0.25 mg/ml in a 1:3 solution of DMSO:PBS (pH 7.2) using this method.
What is the solubility of CPT?
Although CPT is barely soluble (5 μM) in phosphate-buffered saline (PBS), HCPT is slightly more soluble (29 μM). To determine the solubility enhancement, a known concentration of WP6 was stirred with excess solid drug for 3 h in NaD2PO4 buffer (10 mM, pD 7.4).
What is the solubility of camptothecin?
Solubility: Soluble in DMSO (10mg/ml), methanol (40mg/ml), 0.1N sodium hydroxide (50mg/ml) or acetic acid; insoluble in water.
Is camptothecin DMSO soluble?
This product is soluble in DMSO (10 mg/ml). At higher concentrations, heating is required for the product to dissolve completely (approximately 10 minutes at 95 °C), but some precipitation occurs upon cooling to room temperature. It is also soluble in 1 N NaOH (50 mg/ml).
What is CPT in chemistry?
Camptothecin (CPT) is a monoterpene indole alkaloid originally isolated from the bark and stem of Camptotheca acuminata. It has a pentacyclic ring structure bearing a pyrrolo[3,4-β]-quinoline moiety.
What type of compound is camptothecin?
It is a pyranoindolizinoquinoline, a tertiary alcohol, a delta-lactone and a quinoline alkaloid. Camptothecin is an alkaloid isolated from the stem wood of the Chinese tree, Camptotheca acuminata. This compound selectively inhibits the nuclear enzyme DNA topoisomerase, type I.
What is the structure of camptothecin?
Camptothecin (CPT) is a monoterpene indole alkaloid originally isolated from the bark and stem of Camptotheca acuminata. It has a pentacyclic ring structure bearing a pyrrolo[3,4-β]-quinoline moiety.