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Out-of-sign aspects ?

Are they significant? Or, are they much weaker in nature...?

I know real aspects are based on degrees but also the signs have natural aspects to each other, too. For ex, Taurus squares Leo by sign but in a chart I'm perplexed when seeing something like 29° Taurus moon sextile 1° Leo venus...

...I have two in my own chart: 2° Libra mars trine 29° Capricorn neptune and 25° Cancer venus trine 3° Sag pluto. The venus trine pluto confuses me always because not only is it out of sign, but the orb is so wide. I've read about the aspect and don't really relate to it... o.O

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